https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51195 Wed 28 Feb 2024 15:48:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55147 256 mg/L) revealed modified expression of several genes related to membrane transport (porin ompK36 and efflux pump regulator oqxR) and nitroreductase activity (ribC and nfsB, involved in nitrofurantoin reduction). Untargeted metabolomics analysis of total metabolites extracted at 1 and 4 h post-nitrofurantoin treatment revealed that exposure to the drug caused a delayed effect on the metabolome which was most pronounced after 4 h. Pathway enrichment analysis illustrated that several complex interrelated metabolic pathways related to nitrofurantoin bacterial killing (aminoacyl-tRNA biosynthesis, purine metabolism, central carbohydrate metabolism, and pantothenate and CoA biosynthesis) and the development of nitrofurantoin resistance (riboflavin metabolism) were significantly perturbed. This study highlights for the first time the key role of efflux pump regulator oqxR in nitrofurantoin resistance and reveals global metabolome perturbations in response to nitrofurantoin, in K. pneumoniae.]]> Tue 16 Apr 2024 15:16:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52959 Mon 29 Jan 2024 18:42:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54174 Mon 12 Feb 2024 09:35:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51933 Fri 22 Sep 2023 11:06:44 AEST ]]>